Arsenal v Atletico Madrid Predictions: 13/1 Bet Builder Tips & Latest Odds (Champions League)
- Written by Simone Bettarini

Arsenal will face Atletico Madrid on Tuesday in their third Champions League match. Will the Gunners record a sixth consecutive victory or will Diego Simeone's men upset the odds? Read here our Arsenal vs Atletico Madrid predictions with bet builder tips, latest odds, line-ups, team news, betting offers and sign-up offers!
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How to watch Arsenal vs Atletico Madrid
Arsenal welcome Atletico Madrid to the Emirates Stadium in London on Tuesday 21st October 2025, with the match set to kick off at 8 PM.
The will be shown live on Amazon Prime Video in the United Kingdom. Coverage will begin at 6.30pm. Subscribers will be able to watch on the Amazon Prime website or app.
Arsenal vs Atletico Madrid Betting Preview
Arsenal have kicked off their Champions League campaign with two consecutive victories, defeating both Athletic Bilbao and Olympiacos without conceding a single goal (both with a 2-0 scoreline) before the international break. The Gunners are currently on a five-match winning streak across all competitions and are aiming to extend their impressive record of 12 consecutive home games in the Champions League group stage (or league phase) without conceding. In the Premier League, Mikel Arteta's side is three points clear at the top following a narrow 1-0 win over Fulham last weekend.
Atletico Madrid, on the other hand, have faced some challenges domestically. However, a narrow victory over Osasuna has helped them secure three wins in their last four La Liga matches (including a thumping 5-2 win over Real Madrid) after a series of draws. They currently sit fourth in the league, eight points behind their city rivals, Real Madrid. Their only defeat since August came in a 3-2 loss to Liverpool on Matchday 1 of the Champions League, where they were unfortunate not to earn a point after coming back from 2-0 down, thanks to a brace from Marcos Llorente. In their second UCL match, Diego Simeone's side convincingly defeated Eintracht Frankfurt 5-1.
Best Odds
The top betting sites, including crypto betting sites, are showing favouritism to the Gunners who are currently 3/5 (1.60) . The visiting Atletico Madrid side are best priced at 11/2 (6.50) to pick up a shocking away victory, while a draw pays 16/5 (4.30 on non-UK bookmakers).
Probable Line-Ups
Arsenal (4-3-3): Raya; White, Saliba, Gabriel, Lewis-Skelly; Merino, Zubimendi, Rice; Saka, Gyokeres, Martinelli
Mikel Arteta has no new injury concerns following the match against Fulham. Noni Madueke, Kai Havertz, and Martin Odegaard remain unavailable, while Gabriel Jesus is sidelined until at least early 2026. Piero Hincapie has returned to first-team training and is available for selection, though he may not play a significant role. If Arteta decides to rotate his squad, Gabriel Martinelli and Mikel Merino are poised to step into the starting lineup, along with Myles Lewis-Skelly at left-back and Ben White at right-back. Despite not scoring in the last four league matches, Viktor Gyokeres will keep his place up front.
Atletico Madrid (4-4-2): Oblak; Llorente, Lenglet, Le Normand, Hancko; Koke, Barrios, Gallagher, Simeone; Griezmann, Alvarez
Clement Lenglet is back from suspension, and Nico Gonzalez has traveled with the squad despite suffering a head injury during the first half against Osasuna. Johnny Cardoso (ankle) is the only other fitness concern. Giuliano Simeone and Conor Gallagher could return to the Atletico lineup, while Thiago Almada has made a strong case for a starting position after scoring the winner against Osasuna. Antoine Griezmann is expected to partner Julian Alvarez in attack, with Alexander Sørloth providing a further option. A decision is pending on whether Simeone will use conventional full-back Matteo Ruggeri or continue with Dávid Hancko in a makeshift role on the left side of Atletico's defense.
Arsenal vs Atletico Madrid Betting Tips
Arsenal approaches this match in excellent form, having secured five consecutive victories and demonstrating a formidable defensive record, especially in Europe. Alongside Inter Milan, the Gunners are one of only two teams that have yet to concede a goal in this season's Champions League.
On the other hand, Atletico Madrid has struggled on the road, failing to secure a single win away from home, with two losses and three draws in their five away matches. However, Diego Simeone's team has shown considerable attacking prowess this season and could potentially disrupt Arsenal's flawless defensive streak in Europe.
This match has the potential to be another high-scoring affair for Atletico on English soil, and they might just manage to secure at least a draw this time. Therefore, we are backing the "Both teams to score" option and predicting a 2-2 draw in the correct score market.
We also expect a fiercely contested match, which leads us to wager on Over 3.5 cards. For player bets, we suggest Julian Alvarez to have a shot on target.
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Arsenal vs Atletico Madrid Bet Builder Tips
Our team of experts and football enthusiasts at BetAndSkill provides daily bet builder tips. Take advantage of our insights from tipsters and renowned football pundits to outsmart the bookmakers!

Arsenal v Atletico Madrid
Both teams to score
Julian Alvarez 1+ shots on target
Atletico Madrid over 2 corners
Ben White 1+ fouls committed
Over 3 cards
A Bet Builder with these bets pays at approximately 13/1 with Bet365

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